Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials.
Zoe Anne DysonElisheba MalauPaul F HorwoodRebecca FordValentine SibaMition YoannesWilliam PomatMegan Elizabeth PasseyLousie M JuddDanielle J IngleDeborah A WilliamsonGordon DouganAndrew R GreenhillKathryn E HoltPublished in: PLoS neglected tropical diseases (2022)
Antimicrobials remain an effective option for the treatment of typhoid fever in PNG, along with other intervention strategies including improvements to water, sanitation and hygiene (WaSH) related infrastructure and potentially the introduction of Vi-conjugate vaccines. However, continued genomic surveillance is warranted to monitor for the emergence of AMR within local populations, or the introduction of AMR associated genotypes of S. Typhi in this setting.