ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in HER2-positive breast cancer.

Liliana Santos Francesca Tomatis Hugo R S Ferreira Sara F F AlmeidaEdward CiputraJosé SerenoRui Almeida Paulo Teixeira Ana Sofia Ribeiro João Nuno Moreira Ana Paula Silva Lino S Ferreira Antero José AbrunhosaCélia M Gomes

Published in: Neuro-oncology (2024)

We demonstrated that metastatic breast cancer cells exploit the ENPP1 signaling for cell transmigration across the BBB and brain colonization. Our data implicate ENPP1 as a potential biomarker for poor prognosis and early detection of BrM in HER2+ breast cancer.

Keyphrases

blood brain barrier
poor prognosis
cerebral ischemia
positive breast cancer
long non coding rna
breast cancer cells
resting state
white matter
small cell lung cancer
single cell
electronic health record
cell therapy
oxidative stress
stem cells
multiple sclerosis
mesenchymal stem cells
data analysis