Effectiveness and Safety of Compound Polymyxin B Ointment in Treatment of Burn Wounds: A Meta-analysis.

Burn injuries represent a global public health concern. The guidelines for burn care mention that the treatment depends on burn injury depth of tissue, area of wounds, and site on the body. At present, several topical antimicrobial agents are used in treatment of burns wounds as a first choice. This study aims to investigate the effectiveness of the compound polymyxin B topical agents for treatment of burn wounds. PubMed, the Web of Science, ProQuest and China National Knowledge Infrastructure databases were searched for articles published until January 2021. The studies that conducted clinical trials comparing compound polymyxin B ointment with other treatment reagent for burn wound treatment were included. A total of 3 outcomes were investigator-assessed clinical response, including mortality, bacterial counts, efficacy and safety.In total, 12 randomized controlled trials, 1 clinical trial, 2 prospective studies, and 1 retrospective study were extracted. The result of mortality showed no significant difference (risk ratio [RR]: 0.70, 95% CI: 0.21-2.31, P = .56); wound healing revealed [RR]:1.59 (95% CI: 1.40-1.81, P < .001); time to heal revealed a mean difference of -5.09 (95% CI: -6.31 to -3.86) days (P < .001); scar incidence was no significantly lower in the treatment group (RR: 0.70, 95% CI: 0.38-1.30, P = .26); and adverse event incidence was significantly lower in the treatment group (RR: 0.26, 95% CI: 0.09-0.72, P < .01. The compound polymyxin B ointment show the effectiveness of increase the wound healing and accelerate the time of healing with fewer adverse effects.