Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice.
Robin ShoemakerLisa R TannockWen SuMing GongSusan B GurleySean E ThatcherFrederique YiannikourisCharles M EnsorLisa A CassisPublished in: Biology of sex differences (2019)
Adipocyte ACE2 protects female mice from obesity-hypertension, and reduces the blood pressure response to systemic AngII. In obese transwomen undergoing gender-affirming hormone therapy, 17β-estradiol administration may regulate blood pressure via the Ang-(1-7)/AngII balance.
Keyphrases
- blood pressure
- high fat diet induced
- insulin resistance
- adipose tissue
- metabolic syndrome
- weight loss
- angiotensin ii
- hypertensive patients
- type diabetes
- heart rate
- angiotensin converting enzyme
- fatty acid
- obese patients
- bariatric surgery
- mental health
- blood glucose
- glycemic control
- replacement therapy
- smoking cessation