N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.
Rafael Rivas-SantistebanAlejandro LilloJaume LilloJoan-Biel RebassaJoan S ContestíCarlos A SauraRafael FrancoGemma NavarroPublished in: Alzheimer's research & therapy (2021)
The results indicate a negative cross-talk in CB2-NMDA complexes signaling. The expression of the CB2-NMDA receptor heteromers increases in both microglia and neurons from the APPSw/Ind transgenic mice, compared with levels in samples from age-matched control mice.
Keyphrases
- inflammatory response
- induced apoptosis
- neuropathic pain
- poor prognosis
- cell cycle arrest
- spinal cord
- lps induced
- cerebrospinal fluid
- binding protein
- spinal cord injury
- type diabetes
- signaling pathway
- long non coding rna
- high fat diet induced
- oxidative stress
- cell death
- metabolic syndrome
- brain injury
- cerebral ischemia