Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies.
Maria G BelvisiMark A BirrellSaifudin KhalidMichael A WortleyRachel DockryJulie CooteKimberley HoltEric DubuisAngela KelsallSarah A MaherSara BonviniAshley WoodcockJaclyn Ann SmithPublished in: American journal of respiratory and critical care medicine (2017)
CS exposure is capable of inducing responses consistent with phenotypic switching in airway sensory nerves comparable with the cough responses observed in patients with COPD. Moreover, the differing profiles of cough responses support the concept of disease-specific neurophenotypes in airway disease. Clinical trial registered with www.clinicaltrials.gov (NCT 01297790).