Substantial lymph-vascular space invasion (LVSI) as predictor of distant relapse and poor prognosis in low-risk early-stage endometrial cancer.
Lucia TortorellaStefano RestainoGian Franco ZannoniGiuseppe VizzielliVito ChianteraSerena CappuccioAlessandro GioèEleonora La FeraGiorgia DinoiGiuseppe AngelicoGiovanni ScambiaFrancesco FanfaniPublished in: Journal of gynecologic oncology (2021)
Substantial LVSI represents the strongest independent risk factor for decreased survival and distant relapse, indicating a role for potential hematogenous dissemination.