Giant cell tumor of distal radius: En bloc resection with allograft reconstruction: A case report.
Parviz AhangarAlireza RahimniaMohsen AkbaribazmAbbas KhalilpourMohsen RahimiHosein PirmohamadiPublished in: Clinical case reports (2024)
Giant cell tumor of bone (GCT) is a rare neoplasm that affects individuals in their third and fourth decades of life. Clinically, it often presents as a lytic lesion in the epiphyseal region of bones, notably the distal femur and proximal tibia. Radiologically, GCT appears as a distinct lytic lesion in the epiphyseal region. Histopathologically, GCTs are composed of mononuclear cells, macrophages, and multinuclear giant cells, indicative of osteoclastogenic stromal tumors. A 37-year-old man presented with left wrist pain, swelling, and restricted movement persisting for a year, worsening over the last 7 months. Radiographic assessments revealed a distal radius bone mass involving the radiocarpal joint. Biopsy confirmed a GCT with extension into peripheral muscle. PET/CT scan showed localized pathology without metastasis. Histopathologically, GCT exhibited multinucleated giant cells, spindle cells, and aneurysmal bone cyst-like regions with coagulation necrosis. Surgical resection involved en-bloc removal and reconstruction with a non-vascularized radius bone graft. Postoperatively, the patient showed no complications at the one-year follow-up, suggesting successful intervention.
Keyphrases
- induced apoptosis
- cell cycle arrest
- bone mineral density
- pet ct
- giant cell
- endoplasmic reticulum stress
- computed tomography
- randomized controlled trial
- cell death
- chronic pain
- oxidative stress
- bone marrow
- skeletal muscle
- signaling pathway
- low grade
- spinal cord injury
- neuropathic pain
- risk factors
- positron emission tomography
- ultrasound guided