Combinations of Anticyclic Citrullinated Protein Antibody, Rheumatoid Factor, and Serum Calprotectin Positivity Are Associated With the Diagnosis of Rheumatoid Arthritis Within 3 Years.
Leah F BettnerRyan A PetersonDylan T BergstedtLindsay B KelmensonM Kristen DemoruelleTed R MikulsJess D EdisonMark C ParishMarie L FeserAshley A Frazer-AbelLaura K MossMichael MahlerV Michael HolersKevin D DeanePublished in: ACR open rheumatology (2021)
Anti-CCP3, RF-IgM, and sCP are elevated in pre-RA; furthermore, combinations of elevations of these biomarkers are more commonly seen in the period of less than or equal to 3 years to diagnosis. This may be considered in creating inclusion criteria in prevention trials in RA. In addition, the biologic relationships of these biomarkers in pre-RA need exploration.