Age-dependent messenger RNA expression of toll-like receptor 4 and intercellular adhesion molecule-1 in peripheral blood mononuclear cells.

Chiung-Jung WenChin-Hao ChangChin-Ying ChenJen-Kuei PengHsien-Liang HuangPei-Ni ChuangChing-Yu ChenJaw-Shiun Tsai

Published in: European journal of clinical investigation (2021)

The mRNA levels of ICAM-1 and TLR4 in PBMCs are higher in older adults than those in younger adults. TLR4 is an independent factor affecting ICAM-1 expression in PBMCs, especially in older adults. This may suggest that ICAM-1 and TLR4 in PBMCs are potential biomarkers and their relationship may shed some light on the ageing process.

Keyphrases

toll like receptor
inflammatory response
nuclear factor
poor prognosis
immune response
physical activity
binding protein
escherichia coli
cystic fibrosis
cell adhesion
staphylococcus aureus
biofilm formation
pseudomonas aeruginosa
nucleic acid