Clozapine as a first- or second-line treatment in schizophrenia: a systematic review and meta-analysis.
C Okhuijsen-PfeiferE A H HuijsmanA HasanI E C SommerS LeuchtR S KahnJurjen J LuykxPublished in: Acta psychiatrica Scandinavica (2018)
The few eligible trials on this topic suggest that clozapine may be more effective than other antipsychotics when used as first- or second-line treatment. Only large clinical trials may comprehensively probe disease stage-dependent superiority of clozapine and investigate overall tolerability.