EGR2 is elevated and positively regulates inflammatory IFNγ production in lupus CD4+ T cells.

Rujuan DaiBettina HeidXiguang XuHehuang XieChristopher M ReillyS Ansar Ahmed

Published in: BMC immunology (2020)

EGR2 is highly upregulated in human and murine lupus cells. Our in vitro data suggest a positive role of EGR2 in the regulation of Th1 differentiation and IFNγ production in lupus effector CD4+ T cells.

Keyphrases

systemic lupus erythematosus
disease activity
dendritic cells
induced apoptosis
immune response
endothelial cells
rheumatoid arthritis
cell cycle arrest
oxidative stress
regulatory t cells
electronic health record
induced pluripotent stem cells
machine learning
pluripotent stem cells
artificial intelligence