Mechanism of Herb Pairs Astragalus mongholicus and Curcuma phaeocaulis Valeton in Treating Gastric Carcinoma: A Network Pharmacology Combines with Differential Analysis and Molecular Docking.
Zi-Xuan WuXiyang PanChaosheng DengMinjie CaiKai YuanPeidong HuangGuoqi ShiPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
The AM-CPV pharmaceutical combination regulates GC treatment via a multitarget, component, and signal pathway with a cooperative and bidirectional regulatory mechanism. Its active constituents may treat GC by regulating the expression of STAT1, MMP9, IL6, HSP90AA1, JUN, CCL2, IFNG, CXCL8, and other targets, as well as activating or inhibiting immune-inflammatory and cancer signaling pathways.
Keyphrases
- molecular docking
- signaling pathway
- molecular dynamics simulations
- poor prognosis
- papillary thyroid
- pi k akt
- oxidative stress
- transcription factor
- heat shock protein
- cell proliferation
- induced apoptosis
- epithelial mesenchymal transition
- squamous cell
- heat stress
- binding protein
- liver fibrosis
- young adults
- liver injury
- long non coding rna
- childhood cancer
- mass spectrometry
- endoplasmic reticulum stress
- replacement therapy