Association of single nucleotide polymorphisms of cytochrome P450 enzymes with experience of vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients: a systematic review.

Carmen W H ChanBernard M H LawMarques S N NgCorinna C Y WongCarissa W Y WongMorgan QuinleyJessica M OrgusyanKa Ming ChowMary M Y Waye

Published in: BMC cancer (2021)

Overall, genetic variations in CYP have no effect on the experience of hot flashes among breast cancer patients. We recommend exploration of the link between the active metabolites of chemotherapeutic drugs and the molecules shown to affect the occurrence or severity of hot flashes, and the establishment of the relationship between such genetic variations and patients' experience of musculoskeletal and vaginal symptoms. Subgroup analyses based on patients' duration of adjuvant endocrine therapies in such studies are recommended.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
risk assessment
randomized controlled trial
early stage
genome wide
gene expression
ms ms
study protocol