Influence of metformin on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.

Adriana F S FontesFernando M ReisAna Lúcia CândidoKarina Braga GomesJéssica A G Tosatti

Published in: European journal of clinical pharmacology (2023)

We showed that metformin proved to be effective in reducing total testosterone levels, and the same was observed for free androgen index (FAI) values-a measure influenced by testosterone levels. The protocol of this study was registered at Prospero (CRD42021235761).

Keyphrases

polycystic ovary syndrome
replacement therapy
randomized controlled trial
insulin resistance
clinical trial
pregnancy outcomes
pregnant women
smoking cessation