Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.
Rachel M RahnClaire T WeichselbaumDavid H GutmannJoseph D DoughertySusan E MaloneyPublished in: Journal of neurodevelopmental disorders (2021)
These findings suggest that the subcomponents of gait affected in NDDs show overlap between disorders as well as some disorder-specific features, which may change over the course of development. Our incorporation of spatial, temporal, and postural gait measures also provides a template for gait characterization in other NDD models and a platform to examining circuits or longitudinal therapeutics.