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Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.

Rachel M RahnClaire T WeichselbaumDavid H GutmannJoseph D DoughertySusan E Maloney
Published in: Journal of neurodevelopmental disorders (2021)
These findings suggest that the subcomponents of gait affected in NDDs show overlap between disorders as well as some disorder-specific features, which may change over the course of development. Our incorporation of spatial, temporal, and postural gait measures also provides a template for gait characterization in other NDD models and a platform to examining circuits or longitudinal therapeutics.
Keyphrases
  • cerebral palsy
  • mouse model
  • small molecule
  • high throughput
  • cross sectional
  • mass spectrometry
  • high resolution
  • molecularly imprinted
  • liquid chromatography
  • simultaneous determination