Early-pregnancy prediction of risk for pre-eclampsia using maternal blood leptin/ceramide ratio: discovery and confirmation.

Qianyang HuangShiying HaoJin YouXiaoming YaoZhen LiJames SchillingSheeno ThyparambilWei-Li LiaoXin ZhouLihong MoSubhashini LadellaShantay R Davies-BalchHangyi ZhaoDavid FanJohn C WhitinHarvey J CohenDoff B McElhinneyRonald J WongGary M ShawDavid K StevensonKarl G SylvesterXuefeng Bruce Ling

Published in: BMJ open (2021)

Our study demonstrated the longitudinal measurement of maternal Lep/Cer (d18:1/25:0) ratio allows the non-invasive assessment of PE to identify pregnancy at high risk in early gestation, outperforming the established sFlt-1/PlGF ratio test.

Keyphrases

pregnancy outcomes
birth weight
small molecule
preterm infants
gestational age
preterm birth
cross sectional
physical activity