Pd-catalysed synthesis of oxomalonamides through adjacent triple carbonylation of tertiary amines.

Manjunath S Lokolkar Prafull A Jagtap Bhalchandra M Bhanage

Published in: Chemical communications (Cambridge, England) (2024)

The monocarbonylation and dicarbonylation reactions are well-established reactions in carbonylation chemistry. This work reports unusual oxidative adjacent triple carbonylation of the tertiary amine towards oxomalonamide synthesis using a Pd catalyst. The protocol involves the use of inert tertiary amines as an active reservoir of secondary amines through sp 3 C-N bond activation using O 2 as an ideal oxidant.

Keyphrases

randomized controlled trial
room temperature
emergency department
reduced graphene oxide
carbon dioxide
metal organic framework
drug discovery
drug induced