What is the role of lateral lymph node dissection in rectal cancer patients with clinically suspected lateral lymph node metastasis after preoperative chemoradiotherapy? A meta-analysis and systematic review.
Xuyang YangShuo YangTao HuChaoyang GuMingtian WeiXiangbing DengZi-Qiang WangZongguang ZhouPublished in: Cancer medicine (2020)
This is the first meta-analysis and systematic review of studies comparing nCRT+TME and nCRT+TME+LLND for rectal cancer patients. Although increasing operative time and the risk of urinary dysfunction (which might be ameliorated by minimally invasive procedures), the pooled results support the use of LLND after nCRT and TME for reducing LLR in patients with clinically suspected LLNM and provide another treatment option for high-risk patients.
Keyphrases
- systematic review
- rectal cancer
- meta analyses
- minimally invasive
- lymph node metastasis
- locally advanced
- end stage renal disease
- squamous cell carcinoma
- pulmonary embolism
- ejection fraction
- robot assisted
- newly diagnosed
- chronic kidney disease
- prognostic factors
- patients undergoing
- prostate cancer
- lymph node
- randomized controlled trial
- neoadjuvant chemotherapy
- case control
- radical prostatectomy
- open label
- phase iii