Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APP swe and PS1 dE9 mutations.

Guilherme JuvenalCarine MeinerzAna Carolina AyupeHenrique Correia CamposEduardo Moraes ReisBeatriz Monteiro LongoMicheli Mainardi PillatHenning Ulrich

Published in: Cell & bioscience (2024)

BK is an important immunomodulatory agent and enhances the immunological changes identified in transgenic neurospheres carrying the genetic load of AD. Bradykinin treatments modulate the expression rates of genes related to microglia-mediated neuroinflammation. Inhibiting bradykinin activity in Alzheimer's disease may slow disease progression.

Keyphrases

immune response
genome wide
poor prognosis
inflammatory response
signaling pathway
traumatic brain injury
lipopolysaccharide induced
cognitive decline
dna methylation
copy number
binding protein
cognitive impairment
gene expression
cerebral ischemia
transcription factor
subarachnoid hemorrhage
brain injury