Severe Hepatic Insulin Resistance Induces Vascular Dysfunction: Improvement by Liver-Specific Insulin Receptor Isoform A Gene Therapy in a Murine Diabetic Model.

Almudena Gómez-HernándezNatalia de Las HerasAndrea R López-PastorGema García-GómezJorge Infante-Menéndez Paula González-LópezTamara González-IllanesVicente LaheraManuel BenitoOscar Escribano

Published in: Cells (2021)

Severe hepatic insulin resistance is sufficient to produce cardiovascular insulin resistance and dysfunction. Long-term hepatic expression of IRA restored the vascular damage observed in iLIRKO mice.

Keyphrases

insulin resistance
type diabetes
high fat diet induced
gene therapy
adipose tissue
high fat diet
metabolic syndrome
polycystic ovary syndrome
skeletal muscle
oxidative stress
glycemic control
early onset
poor prognosis
binding protein
wild type