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The safety and tolerability of epacadostat alone and in combination with pembrolizumab in patients with advanced solid tumors: results from a first-in-Japanese phase I study (KEYNOTE-434).

Toshihiko DoiYutaka FujiwaraKohei ShitaraToshio ShimizuKan YonemoriNobuaki MatsubaraIzumi OhnoTakahiro KogawaYoichi NaitoLance LeopoldMihaela MunteanuNaoyoshi YatsuzukaShi Rong HanAyman SamkariNoboru Yamamoto
Published in: Investigational new drugs (2020)
Epacadostat in combination with pembrolizumab was generally safe and well tolerated among Japanese patients with advanced solid tumors. Clinical trial registration NCT02862457.
Keyphrases
  • clinical trial
  • open label
  • advanced non small cell lung cancer
  • phase ii
  • double blind
  • randomized controlled trial
  • study protocol
  • epidermal growth factor receptor
  • tyrosine kinase