Established fibrous peritoneal metastasis in an immunocompetent mouse model similar to clinical immune microenvironment of gastric cancer.

Daisuke FujimoriJun KinoshitaTakahisa YamaguchiYusuke NakamuraKatsuya GunjigakeTakashi OhamaKoichi SatoMasami YamamotoTetsuya TsukamotoSachiyo NomuraTetsuo OhtaSachio Fushida

Published in: BMC cancer (2020)

This model is the first immunocompetent mouse model similar to TME of human clinical PM with fibrosis. By using this model, new treatment strategies for PM, such as anti-CAFs therapies, may be developed.

Keyphrases

mouse model
particulate matter
endothelial cells
heavy metals
stem cells
polycyclic aromatic hydrocarbons
water soluble
risk assessment
pluripotent stem cells
liver fibrosis