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CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs.

Kensuke SakumaNoriko Tsubooka-YamazoeKiyohiro HashimotoNozomu SakaiShinya AsanoSaori Watanabe-MatsumotoTakeshi WatanabeBunnai SaitoHirokazu MatsumotoHikaru UenoRyo ItoTaro Toyoda
Published in: Stem cell research & therapy (2023)
Our findings suggest a new risk mitigation approach for cell therapy and advance our understanding of the β-cell differentiation mechanism.
Keyphrases
  • cell therapy
  • induced pluripotent stem cells
  • stem cells
  • endothelial cells
  • mesenchymal stem cells
  • climate change
  • cell cycle
  • pluripotent stem cells
  • cell proliferation
  • breast cancer risk