CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs.
Kensuke SakumaNoriko Tsubooka-YamazoeKiyohiro HashimotoNozomu SakaiShinya AsanoSaori Watanabe-MatsumotoTakeshi WatanabeBunnai SaitoHirokazu MatsumotoHikaru UenoRyo ItoTaro ToyodaPublished in: Stem cell research & therapy (2023)
Our findings suggest a new risk mitigation approach for cell therapy and advance our understanding of the β-cell differentiation mechanism.