Trichoderols B-G, Six New Lipids from the Marine Algicolous Fungus Trichoderma sp. Z43.

Six new lipids, trichoderols B-G ( 1 - 6 ), along with a known one, triharzianin B ( 7 ), were isolated from the culture of Trichoderma sp. Z43 obtained from the surface of the marine brown alga Dictyopteris divaricata . Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1 - 7 were assayed for inhibiting the growth of three phytopathogenic fungi ( Fusarium graminearum , Gaeumannomyces graminis , and Glomerella cingulata ), four marine phytoplankton species ( Amphidinium carterae , Heterocapsa circularisquama , Heterosigma akashiwo , and Prorocentrum donghaiense ), and one marine zooplankton ( Artemia salina ). Compounds 1 , 4 , and 7 exhibited weak antifungal activities against three phytopathogenic fungi tested with MIC ≥ 64 μg/mL. All compounds displayed moderate antimicroalgal activity with IC 50 ≥ 15 μg/mL and low toxicity to the brine shrimp Artemia salina .