Associations of sNfL with clinico-radiological measures in a large MS population.
Elias S SotirchosKathryn C FitzgeraldCarol M SinghMatthew D SmithMaria Reyes-MantillaCarrie M HershMegan H HylandRyan CanissarioSarah B SimmonsGeorgina ArrambideXavier MontalbanManuel Comabella LopezRobert T NaismithMin QiaoLauren B KruppJacqueline A NicholasKatja AkgünTjalf ZiemssenRichard RudickElizabeth FisherRobert A BermelEllen M MowryPeter A CalabresiPublished in: Annals of clinical and translational neurology (2022)
Elevated sNfL is associated with clinical disability, inflammatory disease activity, and whole brain atrophy in MS, but interpretation needs to account for comorbidities including impaired renal function, diabetes, and smoking.
Keyphrases
- disease activity
- multiple sclerosis
- systemic lupus erythematosus
- rheumatoid arthritis
- mass spectrometry
- rheumatoid arthritis patients
- ms ms
- ankylosing spondylitis
- white matter
- juvenile idiopathic arthritis
- type diabetes
- cardiovascular disease
- oxidative stress
- resting state
- smoking cessation
- glycemic control
- cerebral ischemia
- functional connectivity
- adipose tissue
- blood brain barrier