Enhanced Complement Expression in the Tumor Microenvironment Following Neoadjuvant Therapy: Implications for Immunomodulation and Survival in Pancreatic Ductal Adenocarcinoma.

Xiaofei ZhangRuoxin LanYongjun LiuVenu G PillarisettyDanting LiChaohui L ZhaoSuparna A SarkarWeiguo LiuIman HannaMala GuptaCristina HajduJonathan MelamedMichael ShustermanJessica WidmerJohn AllendorfYao-Zhong Liu

Published in: Research square (2024)

NAT can enhance complement production and signaling within the TME, which is associated with reduced immunosuppression in PDAC. These findings suggest that local complement dynamics could serve as a novel biomarker for prognosis, evaluating treatment response and resistance, and guiding therapeutic strategies in NAT-treated PDAC patients.

Keyphrases

newly diagnosed
end stage renal disease
poor prognosis
lymph node
rectal cancer
prognostic factors
locally advanced
stem cells
radiation therapy