Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain).

Fernando Navarro-MateuMari Paz QuesadaTeresa EscámezMª José AlcarázCatherine Seiquer de la PeñaDiego SalmerónJosé María HuertaGemma VilagutMaria Dolores ChirlaqueCarmen NavarroMathilde HuskyRonald C KesslerJordi AlonsoSalvador Martínez

Published in: BMJ open (2019)

Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene-environment interaction were inconclusive.

Keyphrases

risk factors
early life
childhood cancer
genome wide
cross sectional
gene expression
dna methylation