Different types of cartilage neotissue fabricated from collagen hydrogels and mesenchymal stromal cells via SOX9, TGFB1 or BMP2 gene transfer.
Manuel WeißenbergerManuela H WeißenbergerMike WagenbrennerTizian HeinzJenny ReboredoBoris M HolzapfelMaximilian RudertJürgen GrollChristopher H EvansAndre F SteinertPublished in: PloS one (2020)
Different types of neocartilage with varying levels of hypertrophy could be generated from human MSCs in collagen hydrogels by transfer of genes encoding the chondrogenic factors SOX9, TGFB1 and BMP2. This technology may be harnessed for regeneration of specific zones of native cartilage upon damage.
Keyphrases
- mesenchymal stem cells
- wound healing
- extracellular matrix
- tissue engineering
- stem cells
- bone marrow
- transcription factor
- genome wide identification
- umbilical cord
- genome wide
- endothelial cells
- drug delivery
- hyaluronic acid
- bone regeneration
- drug release
- induced pluripotent stem cells
- copy number
- oxidative stress
- pluripotent stem cells
- dna methylation