ALSUntangled 59: Tamoxifen.
Richard BedlackSky Kihuwa-ManiPaul E BarkhausMichael BeremanJames B CaressJesse CrayleGary L PatteeTerry Heiman PattersonPaul WicksNeta ZachGregory T CarterKristiana SalmonPublished in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2021)
Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.