LncRNA SNHG1 enhances cartilage regeneration by modulating chondrogenic differentiation and angiogenesis potentials of JBMMSCs via mitochondrial function regulation.

Hua LiuHuina LiuQiubo YangHaoqing Yang

Published in: Stem cell research & therapy (2024)

The lncRNA SNHG1 promotes chondrogenic differentiation and angiogenesis of JBMMSCs. The lncRNA SNHG1 regulates the phosphorylation of STAT3, reduces the level of ROS, regulates mitochondrial energy metabolism, and ultimately promotes cartilage regeneration.

Keyphrases

poor prognosis
long non coding rna
stem cells
wound healing
mesenchymal stem cells
endothelial cells
long noncoding rna
vascular endothelial growth factor
extracellular matrix
oxidative stress
dna damage
cell death
reactive oxygen species