Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population.

Hyunsuk Lee Jaewon ChoiJong-Il KimRichard M WatanabeNam H ChoKyong-Soo Park Soo Heon Kwak

Published in: Diabetes care (2024)

Individuals with a higher genetic risk for T2D exhibited not only a lower OGTT-derived β-cell function at baseline but also a notably more rapid decline during follow-up. This information could be used to enable a focused precision prevention with lifestyle intervention.

Keyphrases

type diabetes
cardiovascular disease
randomized controlled trial
genome wide
metabolic syndrome
copy number
healthcare
gene expression
dna methylation
glycemic control
quantum dots