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Effect of omega-3 fatty acid diet on prostate cancer progression and cholesterol efflux in tumor-associated macrophages-dependence on GPR120.

Pei LiangSusanne M HenningTristan GroganDavid ElashoffJonathan W SaidPinchas CohenWilliam J Aronson
Published in: Prostate cancer and prostatic diseases (2023)
Host bone marrow cells with functional GPR120 are essential for the anticancer effects of dietary ω-3 fatty acids, and a key target of the ω-3 diet are the M2-like CD206+ macrophages. Our preclinical findings provide rationale for clinical trials evaluating ω-3 fatty acids as a potential therapy for prostate cancer through inhibition of GPR120 functional M2-like macrophages.
Keyphrases
  • fatty acid
  • prostate cancer
  • clinical trial
  • bone marrow
  • radical prostatectomy
  • physical activity
  • weight loss
  • induced apoptosis
  • stem cells
  • risk assessment
  • cell death
  • cell proliferation
  • climate change
  • open label