Health-related quality of life and DNA methylation-based aging biomarkers among survivors of childhood cancer.

Noel-Marie PlonskiYue PanCheng ChenQian DongXijun ZhangNan SongKyla SheltonJohn EastonHeather MulderJinghui Zhang Geoffrey A NealeEmily WalkerHui WangRachel WebsterTara BrinkmanKevin R KrullGregory T ArmstrongKirsten K NessMelissa M HudsonQian LiI-Chan Huang Zhaoming Wang

Published in: Journal of the National Cancer Institute (2024)

Overall and domain-specific measures of HRQOL are associated with DNA methylation measures of biological aging. Future longitudinal studies should test biological aging as a potential mechanism underlying the association between poor HRQOL and increased risk of clinically assessed adverse health outcomes.

Keyphrases

dna methylation
childhood cancer
young adults
genome wide
gene expression
cross sectional
current status
emergency department
copy number
climate change
electronic health record