Impaired adipocyte SLC7A10 promotes lipid storage in association with insulin resistance and altered BCAA metabolism.

Regine Å JersinDivya Sri Priyanka TallapragadaLinn SkartveitMona S BjuneMaheswary MuniandySindre Lee-ØdegårdSini HeinonenMarcus AlvarezKåre Inge BirkelandChristian André DrevonPäivi PajukantaAdrian McCannKirsi H PietiläinenMelina ClaussnitzerGunnar MellgrenSimon Nitter Dankel

Published in: The Journal of clinical endocrinology and metabolism (2023)

Reduced SLC7A10 activity strongly affects flux of BCAAs in adipocytes, which may fuel continued lipogenesis during insulin resistance, and be reflected in increased circulating levels of the valine-derived catabolite 3-HIB.

Keyphrases

insulin resistance
high fat diet induced
adipose tissue
high fat diet
metabolic syndrome
skeletal muscle
polycystic ovary syndrome
type diabetes
fatty acid
glycemic control