Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model.
Ying-Cheng ChenYing-Wei LanShiaw-Min HuangChih-Ching YenWei ChenWan-Ju WuTheresa StaniczekKowit-Yu ChongChuan-Mu ChenPublished in: Stem cell research & therapy (2022)
Our data demonstrated that hAFMSCs strongly inhibit PDAC cell proliferation, tumor growth and invasion, possibly by altering cell cycle arrest and MMP7 signaling-triggered EMT.
Keyphrases
- cell proliferation
- cell cycle arrest
- pi k akt
- mesenchymal stem cells
- mouse model
- umbilical cord
- cell death
- cell migration
- endothelial cells
- cell cycle
- signaling pathway
- epithelial mesenchymal transition
- electronic health record
- induced pluripotent stem cells
- bone marrow
- big data
- pluripotent stem cells
- cell therapy
- artificial intelligence
- data analysis
- deep learning