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Atypical cerebellar functional connectivity at 9 months of age predicts delayed socio-communicative profiles in infants at high and low risk for autism.

Nana J OkadaJanelle LiuTawny TsangErin NoscoNicole M McDonaldKaitlin K CummingsJiwon JungGenevieve PattersonSusan Y BookheimerShulamite A GreenShafali S JesteMirella Dapretto
Published in: Journal of child psychology and psychiatry, and allied disciplines (2021)
We show that hypoconnectivity within distinct cerebro-cerebellar networks in infancy predicts altered socio-communicative development before delays overtly manifest, which may be relevant for early detection and intervention. As the cerebellum is implicated in prediction, our findings point to probabilistic learning as a potential intermediary mechanism that may be disrupted in infancy, cascading into alterations in social communication.
Keyphrases
  • functional connectivity
  • resting state
  • weight gain
  • randomized controlled trial
  • autism spectrum disorder
  • healthcare
  • mental health
  • intellectual disability
  • body mass index
  • human health