Comparison of the Efficacy and Safety of Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation and Concomitant Liver Cirrhosis: A Systematic Review and Meta-Analysis.

Zhi-Yan LeeBoon-Hao SuahYao Hao TeoYao Neng TeoNicholas L X SynTiong-Cheng YeoRaymond C C WongPing ChaiYu Jun WongJamie S Y HoAloysius Sheng-Ting LeowLeonard L L YeoBenjamin Y Q TanChing-Hui Sia

Published in: American journal of cardiovascular drugs : drugs, devices, and other interventions (2021)

Compared with warfarin in patients with AF and liver cirrhosis, DOACs appear to be associated with improved efficacy and safety outcomes. Randomized controlled trials are warranted to confirm these findings.

Keyphrases

direct oral anticoagulants
atrial fibrillation
venous thromboembolism
randomized controlled trial
oral anticoagulants
study protocol
meta analyses
systematic review
skeletal muscle
clinical evaluation
glycemic control