SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo.

Carlos D Cruz-HernándezMarian Cruz-BurgosSergio A Cortés-RamírezAlberto Losada-GarcíaIgnacio Camacho-ArroyoPatricia García-LópezElizabeth LangleyVanessa González-CovarrubiasMonserrat Llaguno-MuniveMartha E Albino-SánchezJosé L Cruz-ColínCarlos Pérez-PlasenciaFredy O Beltrán-AnayaMauricio Rodríguez-Dorantes

Published in: Cancer cell international (2020)

These results suggest the possible role of exogenous SFRP1 protein as a modulator of AR-ERG-WNT signaling network in cells positive to TMPRSS2-ERG. Further, investigation is needed to determine if SFRP1 protein could be a target in against this type of PCa.

Keyphrases

prostate cancer
induced apoptosis
binding protein
poor prognosis
protein protein
radical prostatectomy
amino acid
cell cycle arrest
cell proliferation
endoplasmic reticulum stress
signaling pathway