SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo.
Carlos D Cruz-HernándezMarian Cruz-BurgosSergio A Cortés-RamírezAlberto Losada-GarcíaIgnacio Camacho-ArroyoPatricia García-LópezElizabeth LangleyVanessa González-CovarrubiasMonserrat Llaguno-MuniveMartha E Albino-SánchezJosé L Cruz-ColínCarlos Pérez-PlasenciaFredy O Beltrán-AnayaMauricio Rodríguez-DorantesPublished in: Cancer cell international (2020)
These results suggest the possible role of exogenous SFRP1 protein as a modulator of AR-ERG-WNT signaling network in cells positive to TMPRSS2-ERG. Further, investigation is needed to determine if SFRP1 protein could be a target in against this type of PCa.