Peripheral clinic versus centralized laboratory-based Xpert MTB/RIF performance: Experience gained from a pragmatic, stepped-wedge trial in Botswana.

Tefera AgizewRosanna BoydNdwapi NdwapiAndrew AuldJoyce BasotliSambayawo NyirendaZegabriel TedlaAnikie MathomaUnami MathebulaChawangwa LesediSherri PalsAnand DateHeather AlexanderThomas KuebrichAlyssa Finlay

Published in: PloS one (2017)

Xpert introduction was successful in the Botswana setting. The incidence of unsuccessful test was similar by GeneXpert location (POC vs. centralized laboratory). However, unsuccessful test incidence (15%) in our settings was higher than previously reported and was mostly related to improper sample processing. Ensuring adequate training among Xpert testing staff is essential to minimize errors.

Keyphrases

study protocol
pulmonary tuberculosis
risk factors
mycobacterium tuberculosis
primary care
randomized controlled trial
clinical trial
patient safety
phase iii
phase ii
emergency department
long term care