Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study.
Cathérine DekeyserMatthias HautekeeteMelissa CambronVincent Van PeschFrancesco PattiJens KuhleSamia KhouryJeanette Lechner ScottOliver GerlachAlessandra LugaresiDavide MaimoneAndrea SurcinelliPierre GrammondTomas KalincikMario HabekBarbara WillekensRichard MacdonellPatrice LaliveTunde CsepanyHelmut ButzkuevenCavit BozValentina TomassiniMatteo FoschiJosé Luis Sánchez-MenoyoAyse AltintasSaloua MrabetGerardo IulianoMaria Jose SaRaed AlroughaniRana KarabudakEduardo AgüeraOrla GrayKoen de GansAnneke Van Der WaltPamela A McCombeNorma DeriJustin GarberAbdullah Al-AsmiOlga SkibinaPierre DuquetteElisabetta CartechiniDaniele SpitaleriRiadh GoudierAysun SoysalLiesbeth Van HijfteMark SleeMaria Pia AmatoKatherine BuzzardGuy LaureysPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
In RRMS, the presence of CSF OCBs predicts shorter time to disability milestones, whereas CSF pleocytosis could be protective. This could however not be found in PPMS. CSF pleocytosis is associated with short-term inflammatory disease activity in RRMS. CSF analysis provides prognostic information which could aid in clinical and therapeutic decision-making.