Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis.

Elerson Carlos CostalongaLuiza J de FreitasDeise da S P AragoneFilipe M O SilvaIrene L Noronha

Published in: PloS one (2017)

Our results indicate that VPA suppressed experimental PF through modulation of the TGF-β/Smad pathway. Interestingly, VPA treatment induced a higher expression of antifibrotic factors, such as Smad7. These results suggest that VPA may represent a potential strategy for treating long term PD complications.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
poor prognosis
high glucose
diabetic rats
systemic sclerosis
risk factors
idiopathic pulmonary fibrosis
risk assessment
oxidative stress
signaling pathway
replacement therapy
long non coding rna
smoking cessation
pulmonary fibrosis
liver fibrosis