Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases.
Kevin M SullivanXiuyun JiangPrajna GuhaChristopher LaustedJason A CarterCynthia HsuKevin P LabadieKaran KohliHeidi L KenersonSara K DanielXiaowei YanChangting MengArezou AbbasiMarina ChanY David SeoJames O ParkIan Nicholas CrispeRaymond S YeungTeresa S KimTaranjit S GujralQiang TianSteven C KatzVenu G PillarisettyPublished in: Gut (2022)
Neutralising the effects of IL-10 in human CRLM has therapeutic potential as a stand-alone treatment and to augment the function of adoptively transferred CAR-T cells.