Rhinovirus-Induced Modulation of Epithelial Phenotype: Role in Asthma.
Aubrey N MichiMichelle E LoveDavid M ProudPublished in: Viruses (2020)
Human rhinoviruses have been linked both to the susceptibility of asthma development and to the triggering of acute exacerbations. Given that the human airway epithelial cell is the primary site of human rhinovirus (HRV) infection and replication, the current review focuses on how HRV-induced modulation of several aspects of epithelial cell phenotype could contribute to the development of asthma or to the induction of exacerbations. Modification of epithelial proinflammatory and antiviral responses are considered, as are alterations in an epithelial barrier function and cell phenotype. The contributions of the epithelium to airway remodeling and to the potential modulation of immune responses are also considered. The potential interactions of each type of HRV-induced epithelial phenotypic changes with allergic sensitization and allergic phenotype are also considered in the context of asthma development and of acute exacerbations.
Keyphrases
- chronic obstructive pulmonary disease
- endothelial cells
- high glucose
- allergic rhinitis
- lung function
- drug induced
- cystic fibrosis
- diabetic rats
- immune response
- liver failure
- induced pluripotent stem cells
- pluripotent stem cells
- intensive care unit
- oxidative stress
- cell therapy
- climate change
- mesenchymal stem cells
- risk assessment
- toll like receptor
- dendritic cells
- air pollution
- bone marrow
- inflammatory response
- extracorporeal membrane oxygenation