MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease.
Siwen LiChi Him PoonZhigang ZhangMing YueRuijun ChenYalun ZhangMd Farhad HossainYining PanJun ZhaoLei RongLeung Wing ChuYat Fung SheaEkaterina RogaevaJie TuPeter St George-HyslopLee Wei LimYou-Qiang SongPublished in: CNS neuroscience & therapeutics (2023)
Our findings suggest that miR-128 suppresses AD pathogenesis, and could be a promising therapeutic target for AD. We also find a possible mechanism underlying the dysregulation of miR-128 in AD, in which Aβ reduces miR-128 expression by inhibiting C/EBPα.