Mitochondria-associated endoplasmic reticulum membranes tethering protein VAPB-PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy.

Mingyang LiYonggang ZhangGuixiang YuLijuan GuHua ZhuShi FengXiao-Xing Xiong Zhihong Jian

Published in: CNS neuroscience & therapeutics (2024)

Our findings suggest that the downregulation of VAPB-PTPIP51 expression after IS mediates structural damage to MAMs. This may exacerbate CIRI by inhibiting the PI3K pathway and activating autophagy, thus providing new therapeutic targets for IS.

Keyphrases

signaling pathway
endoplasmic reticulum
cell death
poor prognosis
oxidative stress
binding protein
endoplasmic reticulum stress
atrial fibrillation
protein protein
cell proliferation
small molecule