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Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.

Rakesh KumarNicolas A NunezNeha S JoshiBoney JosephAlessandra VerdeAshok SeshadriAlfredo B Cuellar BarbozaLarry J ProkopGustavo C MedeirosBalwinder Singh
Published in: Bipolar disorders (2024)
This systematic review provides preliminary evidence that ketamine may cause changes in several important pathways involved in energy metabolism and inflammation. Larger and more rigorous studies are needed.
Keyphrases
  • systematic review
  • pain management
  • meta analyses
  • oxidative stress
  • depressive symptoms
  • randomized controlled trial
  • sleep quality
  • chronic pain
  • physical activity