Photoinduced Synthesis of Sulfonyl-Containing Phosphorothioates via a Three-Component Reaction.
Xianda WuMinghong ChenShuiyun ZhengJie WuGang LiuFu-Sheng HePublished in: Molecules (Basel, Switzerland) (2023)
Both sulfonyl and phosphorothioate are important privileged structural motifs which are widely presented in pharmaceuticals and agrochemicals. Herein, we describe an efficient approach to synthesizing sulfonyl-containing phosphorothioates by merging photoredox and copper catalysis at room temperature. This protocol is compatible with a wide range of substrates and can be applied to the late-stage modification of complex molecules. Control experiments are conducted to demonstrate the generation of the sulfonyl radical in the transformation.