Neutral endopeptidase depletion decreases colon cancer cell proliferation and TGF-β1 synthesis in indirect co-cultures with normal colon fibroblasts.

Magdalena Mizerska-Dudka Katarzyna Sawa-Wejksza A Sławińska-Brych M Kandefer-Szerszeń Barbara Zdzisińska

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2021)

The results suggest that the expression of NEP by colon cancer cells is essential for their proliferation and TGF-β1 synthesis during paracrine interactions with NCFs.

Keyphrases

cell proliferation
transforming growth factor
poor prognosis
signaling pathway
cell cycle
epithelial mesenchymal transition
extracellular matrix
binding protein
pi k akt
long non coding rna