A Network Meta-analysis of Dexamethasone for Preventing Post-Extubation Upper Airway Obstruction in Children.

Narayan Prabhu IyerYolanda M López-FernándezSebastián González-DambrauskasArun K BaranwalJustin C HotzMeng ZhuYuan ZhangHannah J CravenElizabeth C WhippleSamer Abu-SultanehRobinder G Khemani

Published in: Annals of the American Thoracic Society (2022)

Peri-extubation dexamethasone can prevent post-extubation UAO in children but effectiveness is highly dependent on timing and dosing regimen. Early initiation (ideally >12 hours prior to extubation) appears to be more important than the dose of dexamethasone. Ultimately the specific steroid strategy should be personalized considering the potential for adverse events associated with dexamethasone and the individual risk of UAO and reintubation.

Keyphrases

cardiac surgery
mechanical ventilation
high dose
low dose
respiratory failure
young adults
acute kidney injury
randomized controlled trial
systematic review
intensive care unit
acute respiratory distress syndrome
risk assessment
extracorporeal membrane oxygenation
human health